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Standard

Height

near HSP90AB2P · rs733047

Strength of the evidence

3 / 4

Its strongest genetic-study result is p = 10−235, with 4 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 4,080,687 European ancestry individuals; replicated in 49,160 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0272 higher (95% confidence interval 0.026-0.029); p = 2 × 10−235.

How common The C allele had a frequency of about 34% in the people studied.

Where it sits Chromosome 4, band 4p15.33 — between genes, 95.4 kb from HSP90AB2P.

How common each version is

CT
Korean KRGDB
C 0.6% · T 99.4%
Korean Korea4K
C 0.4% · T 99.6%
Korean Korea1K
C 0.3% · T 99.7%
Japanese ToMMo
C 0.2% · T 99.8%
Vietnamese
C 4.3% · T 95.7%
World gnomAD
C 33.2% · T 66.8%
World 1000 Genomes
C 30.5% · T 69.5%
World TOPMed
C 33.6% · T 66.4%

By ancestry gnomAD

East Asian
C 1.3% · T 98.7%
European (non-Finnish)
C 33.8% · T 66.2%
African / African American
C 39.4% · T 60.6%
South Asian
C 48.5% · T 51.5%
Admixed American (Latino)
C 27.5% · T 72.5%
Middle Eastern
C 37.1% · T 62.9%
Finnish
C 21.0% · T 79.0%
Ashkenazi Jewish
C 36.8% · T 63.2%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

C/C Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Height. That is a smaller link than two copies.
T/T No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
Source

Quoting this page

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Height (rs733047). MyGeneLog™. https://www.mygenelog.com/variants/rs733047

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