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Haemoglobin concentration (UKB data field 30020)

PRKCE · rs56336893

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻²⁰, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 394,642 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0435 lower (95% confidence interval 0.034-0.053); p = 2 × 10⁻²⁰.

How common The C allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 2, band 2p21 — in an intron of PRKCE.

How common each version is

CT

Korean KRGDB

C 17.5% · T 82.5%

Korean Korea4K

C 15.9% · T 84.1%

Japanese ToMMo

C 16.9% · T 83.1%

Vietnamese

C 14.0% · T 86.0%

World gnomAD

C 5.1% · T 94.9%

World 1000 Genomes

C 9.8% · T 90.2%

World TOPMed

C 5.0% · T 95.0%

By ancestry gnomAD

East Asian

C 17.3% · T 82.7%

European (non-Finnish)

C 3.5% · T 96.5%

African / African American

C 6.1% · T 93.9%

South Asian

C 14.0% · T 86.0%

Admixed American (Latino)

C 3.9% · T 96.1%

Middle Eastern

C 3.1% · T 96.9%

Finnish

C 3.9% · T 96.1%

Ashkenazi Jewish

C 4.0% · T 96.0%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

C/C Two copies of the version the research linked to Haemoglobin concentration (UKB data field 30020). That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Haemoglobin concentration (UKB data field 30020). That is a smaller link than two copies.

T/T No copy of the version the research linked to Haemoglobin concentration (UKB data field 30020). This is the starting point the study compared everyone against.

Source

A scalable variational inference approach for increased mixed-model association power

Loya H, Kalantzis G, Cooper F, Palamara PF

Nature genetics · 2025 · PMID 39789286 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Haemoglobin concentration (UKB data field 30020) (rs56336893). MyGeneLog™. https://www.mygenelog.com/variants/rs56336893

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