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Relative abundance of the human milk microbiota (HMM) Lachnoanaerobaculum sp.

ZBTB8A · rs4970538

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 733 European ancestry, South Asian ancestry, East Asian ancestry, African American or Afro-Caribbean, Other admixed ancestry ancestry, Other ancestry females.

The effect Each copy of the C allele shifted the measure 0.659 higher (95% confidence interval 0.43-0.89); p = 2 × 10⁻⁸.

Where it sits Chromosome 1, band 1p35.1 — in an intron of ZBTB8A.

How common each version is

AC

Korean KRGDB

A 95.5% · C 4.5%

Korean Korea4K

A 96.1% · C 3.9%

Japanese ToMMo

A 95.4% · C 4.6%

Vietnamese

A 94.8% · C 5.2%

World gnomAD

A 87.6% · C 12.3%

World 1000 Genomes

A 89.4% · C 10.6%

World TOPMed

A 87.5% · C 12.5%

By ancestry gnomAD

East Asian

A 94.8% · C 5.2%

European (non-Finnish)

A 89.9% · C 10.1%

African / African American

A 79.9% · C 20.1%

South Asian

A 92.7% · C 7.3%

Admixed American (Latino)

A 91.5% · C 8.5%

Middle Eastern

A 88.8% · C 11.2%

Finnish

A 89.3% · C 10.7%

Ashkenazi Jewish

A 96.0% · C 4.0%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

A/A No copy of the version the research linked to Relative abundance of the human milk microbiota (HMM) Lachnoanaerobaculum sp.. This is the starting point the study compared everyone against.

A/C One copy of the version the research linked to Relative abundance of the human milk microbiota (HMM) Lachnoanaerobaculum sp.. That is a smaller link than two copies.

C/C Two copies of the version the research linked to Relative abundance of the human milk microbiota (HMM) Lachnoanaerobaculum sp.. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization

Fang ZY, Stickley SA, Ambalavanan A, Zhang Y, Zacharias AM, Fehr K, Moossavi S, Petersen C, Miliku K, Mandhane PJ, Simons E, Moraes TJ

and 6 more — show all

Sears MR, Surette MG, Subbarao P, Turvey SE, Azad MB, Duan Q

Cell host & microbe · 2024 · PMID 39293435

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Relative abundance of the human milk microbiota (HMM) Lachnoanaerobaculum sp. (rs4970538). MyGeneLog™. https://www.mygenelog.com/variants/rs4970538

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