Standard

Physical function (baseline)

ACAN · rs4332725

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10⁻²⁹, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 405,979 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.013 lower (95% confidence interval 0.011-0.015); p = 2 × 10⁻²⁹.

How common The C allele had a frequency of about 53% in the people studied.

Where it sits Chromosome 15, band 15q26.1 — in an intron of ACAN.

How common each version is

AC

Korean KRGDB

A 75.0% · C 25.0%

Korean Korea4K

A 65.3% · C 34.7%

Korean Korea1K

A 65.5% · C 34.5%

Japanese ToMMo

A 66.4% · C 33.6%

World gnomAD

A 42.7% · C 57.3%

World 1000 Genomes

A 57.6% · C 42.4%

By ancestry gnomAD

East Asian

A 71.4% · C 28.6%

European (non-Finnish)

A 40.0% · C 60.0%

African / African American

A 33.8% · C 66.2%

South Asian

A 48.9% · C 51.1%

Admixed American (Latino)

A 51.4% · C 48.6%

Middle Eastern

A 31.0% · C 69.0%

Finnish

A 54.3% · C 45.7%

Ashkenazi Jewish

A 32.2% · C 67.8%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

A/A No copy of the version the research linked to Physical function (baseline). This is the starting point the study compared everyone against.

A/C One copy of the version the research linked to Physical function (baseline). That is a smaller link than two copies.

C/C Two copies of the version the research linked to Physical function (baseline). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline

Schoeler T, Pingault JB, Kutalik Z

Nature communications · 2025 · PMID 40374629 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Physical function (baseline) (rs4332725). MyGeneLog™. https://www.mygenelog.com/variants/rs4332725

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