Links from this page to related variants, conditions, drugs and topics are not included for automated readers. Those connections are the Gene Knowledge Graph and are licensed as data: https://www.mygenelog.com/license
1 3422118223310Reads by AI crawlersClaude2ChatGPT2Google · Gemini1Perplexity1Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others10Total34Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−14, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 564,698 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0153 lower (95% confidence interval 0.011-0.019); p = 4 × 10−15.
How common The G allele had a frequency of about 47% in the people studied.
Where it sits Chromosome 7, band 7p22.2 — in an intron of SDK1.
How common each version is
AG
KoreanKRGDB
A 36.5% · G 63.5%
KoreanKorea4K
A 36.7% · G 63.3%
KoreanKorea1K
A 36.8% · G 63.2%
Japanese ToMMo
A 34.5% · G 65.5%
Vietnamese
A 31.6% · G 68.4%
World gnomAD
A 52.2% · G 47.8%
World 1000 Genomes
A 55.5% · G 44.5%
World TOPMed
A 52.2% · G 47.8%
By ancestry gnomAD
East Asian
A 39.5% · G 60.5%
European (non-Finnish)
A 52.2% · G 47.8%
African / African American
A 48.3% · G 51.7%
South Asian
A 74.9% · G 25.1%
Admixed American (Latino)
A 60.6% · G 39.4%
Middle Eastern
A 56.5% · G 43.5%
Finnish
A 49.8% · G 50.2%
Ashkenazi Jewish
A 57.9% · G 42.1%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.
What each result means
A/ANo copy of the version the research linked to Self-reported math ability. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Self-reported math ability. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Self-reported math ability. That is the strongest link of the three results. A link in a study is not a diagnosis.
1 3422118223310Reads by AI crawlersClaude2ChatGPT2Google · Gemini1Perplexity1Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others10Total34Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Self-reported math ability (rs4257931). MyGeneLog™. https://www.mygenelog.com/variants/rs4257931