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Standard

Height

near RAPSN · rs4237544

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−19, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 293,593 African ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0246 higher (95% confidence interval 0.019-0.03); p = 2 × 10−19.

How common The A allele had a frequency of about 56% in the people studied.

Where it sits Chromosome 11, band 11p11.2 — between genes, 5 kb from RAPSN.

How common each version is

AC
Korean KRGDB
A 41.6% · C 58.4%
Korean Korea4K
A 42.2% · C 57.8%
Japanese ToMMo
A 43.9% · C 56.1%
Vietnamese
A 30.1% · C 69.9%
World gnomAD
A 37.7% · C 62.3%
World 1000 Genomes
A 37.5% · C 62.5%
World TOPMed
A 38.3% · C 61.7%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Height. That is a smaller link than two copies.
C/C No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
Source

Quoting this page

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Height (rs4237544). MyGeneLog™. https://www.mygenelog.com/variants/rs4237544

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