Sensitive

Ischemic stroke in dyslipidemia

ULK4 · rs3897976

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 295 Korean ancestry cases, 20,474 Korean ancestry controls.

The effect Each copy of the A allele carried 2.16 times the odds of Ischemic stroke in dyslipidemia (95% confidence interval 1.646-2.84); p = 3 × 10⁻⁸.

How common The A allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 3, band 3p22.1 — in an intron of ULK4.

How common each version is

AG

Korean KRGDB

A 4.5% · G 95.5%

Korean Korea4K

A 5.2% · G 94.8%

Japanese ToMMo

A 4.4% · G 95.6%

Vietnamese

A 5.2% · G 94.8%

World gnomAD

A 9.2% · G 90.8%

World 1000 Genomes

A 7.5% · G 92.5%

World TOPMed

A 8.8% · G 91.2%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to Ischemic stroke in dyslipidemia. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Ischemic stroke in dyslipidemia. That is a smaller link than two copies.

G/G No copy of the version the research linked to Ischemic stroke in dyslipidemia. This is the starting point the study compared everyone against.

Source

Identification of susceptibility loci for cardiovascular disease in adults with hypertension, diabetes, and dyslipidemia

Song Y, Choi JE, Kwon YJ, Chang HJ, Kim JO, Park DH, Park JM, Kim SJ, Lee JW, Hong KW

Journal of translational medicine · 2021 · PMID 33632238 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Ischemic stroke in dyslipidemia (rs3897976). MyGeneLog™. https://www.mygenelog.com/variants/rs3897976

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