Sensitive

Lucey-Driscoll syndrome

UGT1A1 · rs3755319

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 0 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic for Lucey-Driscoll syndrome; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2000-11-01. ClinVar record 12282 NC_000002.12:g.233758936=

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-11-09 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

How common each version is

AC

Korean KRGDB

A 72.0% · C 28.0%

Korean Korea4K

A 71.6% · C 28.4%

Korean Korea1K

A 71.1% · C 28.9%

Japanese ToMMo

A 75.5% · C 24.4%

Vietnamese

A 65.4% · C 34.6%

World 1000 Genomes

A 45.0% · C 55.0%

World TOPMed

A 47.5% · C 52.5%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

ClinVar's record for this position describes the reference version of the DNA itself, the version written in the reference genome, not a change from it. So this page does not say what any result means: the record cannot be read as "this genotype causes the condition". ClinVar's own call, and how far it was reviewed, are shown above.

Source: ClinVar VCV000012282, no assertion criteria provided

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Lucey-Driscoll syndrome (rs3755319). MyGeneLog™. https://www.mygenelog.com/variants/rs3755319

← See all variants