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Standard

Height

ZNF438 · rs2994652

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−22, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 472,730 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0235 higher (95% confidence interval 0.019-0.028); p = 6 × 10−23.

How common The A allele had a frequency of about 43% in the people studied.

Where it sits Chromosome 10, band 10p11.23 — inside ZNF438.

How common each version is

AG
Korean KRGDB
A 41.4% · G 58.6%
Korean Korea4K
A 43.9% · G 56.1%
Korean Korea1K
A 44.0% · G 56.0%
Japanese ToMMo
A 41.9% · G 58.1%
Vietnamese
A 51.4% · G 48.6%
World gnomAD
A 54.0% · G 46.0%
World 1000 Genomes
A 47.8% · G 52.2%
World TOPMed
A 54.4% · G 45.6%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Height. That is a smaller link than two copies.
G/G No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
Source

Quoting this page

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Height (rs2994652). MyGeneLog™. https://www.mygenelog.com/variants/rs2994652

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