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Standard

Height

near KLHL25 · rs2937952

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 455,180 Hispanic or Latin American individuals.

The effect Each copy of the T allele shifted the measure 0.0194 higher (95% confidence interval 0.013-0.026); p = 1 × 10−8.

How common The T allele had a frequency of about 12% in the people studied.

Where it sits Chromosome 15, band 15q25.3 — between genes, 2.3 kb from KLHL25.

How common each version is

CT
Korean KRGDB
C 64.2% · T 35.8%
Korean Korea4K
C 64.5% · T 35.5%
Vietnamese
C 71.3% · T 28.7%
World gnomAD
C 87.0% · T 13.0%
World 1000 Genomes
C 81.3% · T 18.7%
World TOPMed
C 88.0% · T 12.0%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Height. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Quoting this page

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Height (rs2937952). MyGeneLog™. https://www.mygenelog.com/variants/rs2937952

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