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HIV-1 control

HLA-B · rs2523590

Where this position leads

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs2523590 Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs2523590 rs2523590 HLA-B

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of HIV-1 control compared to the general population. (GWAS Catalog, Science 2010, PMID:21051598)
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with HIV-1 control. (GWAS Catalog, Science 2010, PMID:21051598)
T/T Published research associates this genotype with typical/baseline likelihood of HIV-1 control — no copies of the reported risk allele. (GWAS Catalog, Science 2010, PMID:21051598)

Source: GWAS Catalog, Science 2010, PMID:21051598

Questions about rs2523590

What is rs2523590?

rs2523590 is a single position in the genome, in or near the HLA-B gene. Published research associates it with hiv-1 control. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs2523590 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs2523590 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2523590 come from?

GWAS Catalog, Science 2010, PMID:21051598. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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