Standard

Response to statins (HDL cholesterol change)

CETP · rs247616

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

3 / 4

Its strongest genetic-study result is p = 10⁻³⁰⁰, with 163 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

How common each version is

CT

Korean KRGDB

C 84.0% · T 16.0%

Korean Korea4K

C 83.6% · T 16.4%

Korean Korea1K

C 83.0% · T 17.0%

Japanese ToMMo

C 79.1% · T 20.9%

Vietnamese

C 80.6% · T 19.4%

World gnomAD

C 70.9% · T 29.1%

World 1000 Genomes

C 73.2% · T 26.8%

World TOPMed

C 71.2% · T 28.8%

By ancestry gnomAD

East Asian

C 83.5% · T 16.5%

European (non-Finnish)

C 67.7% · T 32.4%

African / African American

C 74.4% · T 25.6%

South Asian

C 66.6% · T 33.4%

Admixed American (Latino)

C 71.3% · T 28.7%

Middle Eastern

C 76.4% · T 23.6%

Finnish

C 72.4% · T 27.6%

Ashkenazi Jewish

C 73.5% · T 26.5%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

C/C No copy of the version the research linked to Response to statins (HDL cholesterol change). This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Response to statins (HDL cholesterol change). That is a smaller link than two copies.

T/T Two copies of the version the research linked to Response to statins (HDL cholesterol change). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE, Deshmukh HA, Evans DS, Feng Q, Li X

and 76 more — show all

Smit RA, Smith AV, Sun F, Taylor KD, Arnold AM, Barnes MR, Barratt BJ, Betteridge J, Boekholdt SM, Boerwinkle E, Buckley BM, Chen YI, de Craen AJ, Cummings SR, Denny JC, Dubé MP, Durrington PN, Eiriksdottir G, Ford I, Guo X, Harris TB, Heckbert SR, Hofman A, Hovingh GK, Kastelein JJ, Launer LJ, Liu CT, Liu Y, Lumley T, McKeigue PM, Munroe PB, Neil A, Nickerson DA, Nyberg F, O'Brien E, O'Donnell CJ, Post W, Poulter N, Vasan RS, Rice K, Rich SS, Rivadeneira F, Sattar N, Sever P, Shaw-Hawkins S, Shields DC, Slagboom PE, Smith NL, Smith JD, Sotoodehnia N, Stanton A, Stott DJ, Stricker BH, Stürmer T, Uitterlinden AG, Wei WQ, Westendorp RG, Whitsel EA, Wiggins KL, Wilke RA, Ballantyne CM, Colhoun HM, Cupples LA, Franco OH, Gudnason V, Hitman G, Palmer CN, Psaty BM, Ridker PM, Stafford JM, Stein CM, Tardif JC, Caulfield MJ, Jukema JW, Rotter JI, Krauss RM

Journal of medical genetics · 2016 · PMID 27587472

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Response to statins (HDL cholesterol change) (rs247616). MyGeneLog™. https://www.mygenelog.com/variants/rs247616

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