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HIV-1 control

HLA-B · rs2395029

Where this position leads

Condition: Abacavir Hypersensitivity (HLA-B*57:01)

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs2395029 Condition: Abacavir Hypersensitivity (HLA-B*57:01) Abacavir Hypersensitivity (HLA-B*57:01) Condition Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs2395029 rs2395029 HLA-B

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of HIV-1 control compared to the general population. (GWAS Catalog, Science 2010, PMID:21051598)
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with HIV-1 control. (GWAS Catalog, Science 2010, PMID:21051598)
T/T Published research associates this genotype with typical/baseline likelihood of HIV-1 control — no copies of the reported risk allele. (GWAS Catalog, Science 2010, PMID:21051598)

Source: GWAS Catalog, Science 2010, PMID:21051598

What people read about alongside this

Infection and immunity1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs2395029

What is rs2395029?

rs2395029 is a single position in the genome, in or near the HLA-B gene. Published research associates it with hiv-1 control. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2395029 linked to?

On MyGeneLog this position is linked to Abacavir Hypersensitivity (HLA-B*57:01). The research behind each link, and its sources, are set out on that condition page.

Does rs2395029 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

What do people read about alongside rs2395029?

Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs2395029 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2395029 come from?

GWAS Catalog, Science 2010, PMID:21051598. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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