Standard

Chronotype

THRB · rs2362775

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 449,734 European ancestry individuals; replicated in 248,098 European ancestry individuals.

The effect The reported allele is C; the catalogue records no effect size ; p = 6 × 10⁻⁹.

How common The C allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 3, band 3p24.2 — in an intron of RARB.

How common each version is

CT

Korean KRGDB

C 19.1% · T 80.8%

Korean Korea4K

C 18.4% · T 81.6%

Korean Korea1K

C 17.8% · T 82.2%

Japanese ToMMo

C 21.7% · T 78.3%

Vietnamese

C 10.8% · T 89.1%

World gnomAD

C 34.0% · T 66.0%

World 1000 Genomes

C 26.6% · T 73.4%

World TOPMed

C 31.7% · T 68.3%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C Two copies of the version the research linked to Chronotype. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Chronotype. That is a smaller link than two copies.

T/T No copy of the version the research linked to Chronotype. This is the starting point the study compared everyone against.

Source

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, Tuke MA, Yaghootkar H

and 20 more — show all

Nature communications · 2019 · PMID 30696823 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Chronotype (rs2362775). MyGeneLog™. https://www.mygenelog.com/variants/rs2362775

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