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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−11, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 49,733 European ancestry cases, 963,748 European ancestry controls, 19 East Asian ancestry cases, 2,184 East Asian ancestry controls, 74 African or African American cases, 7,319 African or African American controls, 48 South Asian ancestry cases, 7,921 South Asian ancestry controls.
The effect
Each copy of the A allele carried 1.05 times the odds of Osteoarthritis (with total hip replacement) (95% confidence interval 1.03686347834782-1.06779922362004); p = 9 × 10−12.
How common The A allele had a frequency of about 33% in the people studied.
Where it sits Chromosome 17, band 17q22 — between genes, 94.7 kb from C17orf67.
How common each version is
AC
KoreanKRGDB
A 23.5% · C 76.5%
KoreanKorea4K
A 21.8% · C 78.2%
KoreanKorea1K
A 20.8% · C 79.1%
Japanese ToMMo
A 26.9% · C 73.2%
Vietnamese
A 20.1% · C 79.9%
World gnomAD
A 28.9% · C 71.1%
World 1000 Genomes
A 26.8% · C 73.2%
World TOPMed
A 27.3% · C 72.8%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
A/ATwo copies of the version the research linked to Osteoarthritis (with total hip replacement). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Osteoarthritis (with total hip replacement). That is a smaller link than two copies.
C/CNo copy of the version the research linked to Osteoarthritis (with total hip replacement). This is the starting point the study compared everyone against.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Osteoarthritis (with total hip replacement) (rs227729). MyGeneLog™. https://www.mygenelog.com/variants/rs227729