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Apolipoprotein A1 levels

DYM · rs2156498

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁹, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 311,601 European ancestry individuals, 5,550 African ancestry individuals, 6,682 South Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0656 lower (95% confidence interval 0.045-0.086); p = 7 × 10⁻¹⁰.

Where it sits Chromosome 18, band 18q21.1 — in an intron of DYM.

How common each version is

AG

World gnomAD

A 99.3% · G 0.7%

World 1000 Genomes

A 99.8% · G 0.2%

World TOPMed

A 99.3% · G 0.7%

By ancestry gnomAD

East Asian

A 100.0%

European (non-Finnish)

A 98.8% · G 1.2%

African / African American

A 99.8%

South Asian

A 99.9%

Admixed American (Latino)

A 99.6%

Finnish

A 99.6%

Ashkenazi Jewish

A 99.4% · G 0.6%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races. No Korean figure for this position yet.

What each result means

A/A No copy of the version the research linked to Apolipoprotein A1 levels. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Apolipoprotein A1 levels. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Apolipoprotein A1 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genetics of 35 blood and urine biomarkers in the UK Biobank

Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP

and 11 more — show all

Qian J, Shcherbina A, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA

FinnGen

Nature genetics · 2021 · PMID 33462484 · open access

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Apolipoprotein A1 levels (rs2156498). MyGeneLog™. https://www.mygenelog.com/variants/rs2156498

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