Links from this page to related variants, conditions, drugs and topics are not included for automated readers. Those connections are the Gene Knowledge Graph and are licensed as data: https://www.mygenelog.com/license
0 374218222115Reads by AI crawlersClaude4ChatGPT2Google · Gemini0Perplexity1Meta AI8Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others15Total37Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
2 / 4
Its strongest genetic-study result is p = 10−21, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 14,498 European ancestry cases, 24,091 European ancestry controls; replicated in 14,802 European ancestry cases, 26,703 European ancestry controls.
The effect
Each copy of the A allele carried 1.13 times the odds of Multiple sclerosis (95% confidence interval -); p = 9 × 10−22.
How common The A allele had a frequency of about 67% in the people studied.
Where it sits Chromosome 12, band 12q14.1 — in an intron of TSFM.
How common each version is
AT
KoreanKRGDB
A 93.1% · T 6.9%
Japanese ToMMo
A 99.9% · T 0.1%
By ancestry gnomAD
East Asian
A 100.0%
European (non-Finnish)
A 99.9%
African / African American
A 99.9%
South Asian
A 99.9%
Admixed American (Latino)
A 99.9%
Finnish
A 99.0% · T 1.0%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.
What each result means
A/ATwo copies of the version the research linked to Multiple sclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Multiple sclerosis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Multiple sclerosis. This is the starting point the study compared everyone against.
Nature genetics · 2013 · PMID 24076602 · open access
0 374218222115Reads by AI crawlersClaude4ChatGPT2Google · Gemini0Perplexity1Meta AI8Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others15Total37Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license