Sensitive

Creutzfeldt-Jakob disease

PRNP · rs1799990

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Creutzfeldt-Jakob disease compared to the general population. (GWAS Catalog, Lancet Neurol 2008, PMID:19081515)

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Creutzfeldt-Jakob disease. (GWAS Catalog, Lancet Neurol 2008, PMID:19081515)

G/G Published research associates this genotype with typical/baseline likelihood of Creutzfeldt-Jakob disease — no copies of the reported risk allele. (GWAS Catalog, Lancet Neurol 2008, PMID:19081515)

Source: GWAS Catalog, Lancet Neurol 2008, PMID:19081515

Questions about rs1799990

What is rs1799990?

rs1799990 is a single position in the genome, in or near the PRNP gene. Published research associates it with creutzfeldt-jakob disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1799990 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1799990 come from?

GWAS Catalog, Lancet Neurol 2008, PMID:19081515. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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