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Standard

Total cholesterol levels

CWF19L1 · rs17668357

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−22, with 3 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0162 higher (95% confidence interval 0.014-0.019); p = 4 × 10−23.

How common The C allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 10, band 10q24.31 — in an intron of CWF19L1.

How common each version is

CG
Korean KRGDB
C 5.3% · G 94.7%
Korean Korea4K
C 5.3% · G 94.7%
Korean Korea1K
C 5.2% · G 94.8%
Japanese ToMMo
C 4.1% · G 95.9%
Vietnamese
C 6.5% · G 93.5%
World gnomAD
C 28.8% · G 71.2%
World 1000 Genomes
C 17.2% · G 82.8%
World TOPMed
C 27.8% · G 72.2%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C Two copies of the version the research linked to Total cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Total cholesterol levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Total cholesterol levels. This is the starting point the study compared everyone against.
Source

Quoting this page

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Total cholesterol levels (rs17668357). MyGeneLog™. https://www.mygenelog.com/variants/rs17668357

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