Links from this page to related variants, conditions, drugs and topics are not included for automated readers. Those connections are the Gene Knowledge Graph and are licensed as data: https://www.mygenelog.com/license
Raynaud's Syndrome, as genome-wide studies have reported it: 5 positions from 2 studies, the largest recording 11,358 cases and 1,106,871 controls (European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
2 studies in the GWAS Catalog report 5 positions for Raynaud's Syndrome, which the catalogue files as "Raynaud's syndrome". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Tervi A et al. 2024, in Cell Genomics — Genetic and functional analysis of Raynaud's syndrome implicates loci in vasculature and immunity. Sample in the catalogue's record: 11,358 cases and 1,106,871 controls (European ancestry). From it, 3 positions on this page: rs7706161 (near LINC02063), rs191137443 (near LINC01256), rs7601792 (near LINC01854). PMID:39142284.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. The catalogue records its sample as 2,581 cases and 569,155 controls (African American or Afro-Caribbean ancestry, European ancestry). The 2 positions on this page from it: rs563299396 (near LINC01489), rs376381515 (ARVCF). PMID:39024449.
The catalogue maps the 5 positions to 5 genes: LINC02063, LINC01256, LINC01854, LINC01489, ARVCF. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Tervi A et al. 2024 reported the smallest P value on this page — P = 4 × 10-26 — at rs7706161 near LINC02063.
Read this page as a list of findings about Raynaud's Syndrome, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
A genotype does not diagnose Raynaud's Syndrome; a clinician does. No guideline uses the 5 variants on this page to predict it, screen for it or confirm it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
Databases, guidelines and references
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Raynaud's Syndrome. MyGeneLog™. https://www.mygenelog.com/conditions/raynauds-syndrome
In the GWAS Catalog, Raynaud's Syndrome is filed as "Raynaud's syndrome". Rather than define it, this page lists the genome-wide findings: 5 positions from 2 studies, each with its study's sample and citation.
Genome-wide studies have reported 5 associated positions; the largest study behind this page recorded 11,358 cases and 1,106,871 controls (European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 5 genes: LINC02063, LINC01256, LINC01854, LINC01489, ARVCF. These are where the positions sit, not proof of how they act.
No. They are population-level findings of small effect. Raynaud's Syndrome is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse, non-commercially. This page's text is original writing from freely-available research, licensed CC BY-NC 4.0 — share and adapt it with attribution to MyGeneLog™; commercial use is licensed. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.