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Lynch Syndrome 1, as genome-wide studies have reported it: 33 positions from 1 study. Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
Lynch Syndrome 1 — filed in the GWAS Catalog as "Lynch syndrome 1" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 33 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
A study. It contributes 33 positions: rs147542208 (MLH1), rs1553350250 (MSH2), rs1553412495 (MSH6), rs1558466577 (MSH2), rs1558664787 (MSH6), rs1559543768 (MLH1), rs1573437173 (MSH2), rs193922376 (MSH2), and 25 more.
The catalogue maps the 33 positions to 3 genes: MLH1, MSH2, MSH6. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
It is a record of what genome-wide studies have reported about Lynch Syndrome 1, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Lynch Syndrome 1 is diagnosed by a clinician — not from a genotype. None of the 33 variants on this page is used by any guideline to predict, screen for or diagnose it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
Databases, guidelines and references
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Lynch Syndrome 1. MyGeneLog™. https://www.mygenelog.com/conditions/lynch-syndrome-1
In the GWAS Catalog, Lynch Syndrome 1 is filed as "Lynch syndrome 1". Rather than define it, this page lists the genome-wide findings: 33 positions from 1 study, each with its study's sample and citation.
Genome-wide studies have reported 33 associated positions. Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 3 genes: MLH1, MSH2, MSH6. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Lynch Syndrome 1 is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse, non-commercially. This page's text is original writing from freely-available research, licensed CC BY-NC 4.0 — share and adapt it with attribution to MyGeneLog™; commercial use is licensed. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.