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Lofgren's Syndrome, as genome-wide studies have reported it: 9 positions from 1 study, the largest recording 132 cases and 2,236 controls (European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Genome-wide studies have so far placed 9 positions on Lofgren's Syndrome, from 1 study; the GWAS Catalog files the condition as "Lofgren's syndrome". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Xiong Y et al. 2023, in Frontiers in Medicine — Sex differences in the genetics of sarcoidosis across European and African ancestry populations. The catalogue records its sample as 132 cases and 2,236 controls (European ancestry). The 9 positions on this page from it: rs1064627 (FLOT1), rs4143332 (ZDHHC20P2), rs886423 (LINC00243), rs2105902 (near HLA-DRA), rs2233974 (C6orf15), rs3129963 (near TSBP1-AS1), rs2524069 (USP8P1), rs3094049 (near MICC), and 1 more. PMID:37250650.
The 9 positions sit in or beside 9 genes: FLOT1, ZDHHC20P2, LINC00243, HLA-DRA, C6orf15, TSBP1-AS1, USP8P1, MICC, ZSCAN16-AS1. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
The strongest association in the records is rs1064627 in FLOT1, reported by Xiong Y et al. 2023 at P = 3 × 10-14, with an odds ratio of 3.31.
Association records say which positions differ, on average, between people with Lofgren's Syndrome and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Nothing on this page diagnoses Lofgren's Syndrome. The 9 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
Databases, guidelines and references
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Lofgren's Syndrome. MyGeneLog™. https://www.mygenelog.com/conditions/lofgrens-syndrome
Lofgren's Syndrome is the condition the GWAS Catalog files under "Lofgren's syndrome". This page does not define it in its own words; it lists what genome-wide studies have reported: 9 positions from 1 study, with each study's sample and citation.
Genes play a part: 9 positions have been linked to it, the largest study recording 132 cases and 2,236 controls (European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 9 genes: FLOT1, ZDHHC20P2, LINC00243, HLA-DRA, C6orf15, TSBP1-AS1, USP8P1, MICC, ZSCAN16-AS1. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Lofgren's Syndrome is diagnosed by a clinician, and no guideline uses a genotype to predict it.
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