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Ichthyosis Linearis Circumflexa, as genome-wide studies have reported it: 29 positions from 1 study. Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
1 study in the GWAS Catalog report 29 positions for Ichthyosis Linearis Circumflexa, which the catalogue files as "Ichthyosis linearis circumflexa". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
A study. It contributes 29 positions: rs1057518067 (SPINK5), rs1057520643 (SPINK5), rs1212676320 (SPINK5), rs1219497521 (SPINK5), rs1309309448 (SPINK5), rs1340491788 (SPINK5), rs1394583450 (SPINK5), rs1480221716 (SPINK5), and 21 more.
The 29 positions lie in or near 1 gene: SPINK5. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Association records say which positions differ, on average, between people with Ichthyosis Linearis Circumflexa and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Ichthyosis Linearis Circumflexa is diagnosed by a clinician — not from a genotype. None of the 29 variants on this page is used by any guideline to predict, screen for or diagnose it.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
Databases, guidelines and references
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Ichthyosis Linearis Circumflexa. MyGeneLog™. https://www.mygenelog.com/conditions/ichthyosis-linearis-circumflexa
In the GWAS Catalog, Ichthyosis Linearis Circumflexa is filed as "Ichthyosis linearis circumflexa". Rather than define it, this page lists the genome-wide findings: 29 positions from 1 study, each with its study's sample and citation.
Genes play a part: 29 positions have been linked to it. But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 1 gene: SPINK5. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Ichthyosis Linearis Circumflexa from a genotype; a clinician diagnoses it.
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