Hypocalcemia, as genome-wide studies have reported it: 8 positions from 1 study, the largest recording 3,109 cases and 624,208 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Hypocalcemia — filed in the GWAS Catalog as "Hypocalcemia (PheCode 275.51)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 8 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 3,109 cases and 624,208 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). The 8 positions on this page from it: rs190519820 (near LINC02476), rs145620191 (PTPRZ1), rs142608816 (CAPZA2), rs562972265 (ST6GALNAC3), rs537815909 (ZNF208), rs552257275 (EYA1), rs949560577 (UNC5C), rs535531538 (EML6). PMID:39024449.
The 8 positions sit in or beside 8 genes: LINC02476, PTPRZ1, CAPZA2, ST6GALNAC3, ZNF208, EYA1, UNC5C, EML6. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Verma A et al. 2024 reported the smallest P value on this page — P = 3 × 10-12 — at rs190519820 near LINC02476.
Association records say which positions differ, on average, between people with Hypocalcemia and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Nothing on this page diagnoses Hypocalcemia. The 8 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Hypocalcemia comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Hypocalcemia. MyGeneLog™. https://www.mygenelog.com/conditions/hypocalcemia
Hypocalcemia is the condition the GWAS Catalog files under "Hypocalcemia (PheCode 275.51)". This page does not define it in its own words; it lists what genome-wide studies have reported: 8 positions from 1 study, with each study's sample and citation.
Genome-wide studies have reported 8 associated positions; the largest study behind this page recorded 3,109 cases and 624,208 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 8 genes: LINC02476, PTPRZ1, CAPZA2, ST6GALNAC3, ZNF208, EYA1, UNC5C, EML6. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Hypocalcemia from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.