Duodenitis, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 2,938 cases and 619,683 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Duodenitis — filed in the GWAS Catalog as "Duodenitis (PheCode 535.6)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 5 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 2,938 cases and 619,683 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). It contributes 5 positions: rs529554850 (near TRERNA1), rs552149410 (PAM16), rs566950676 (TBX19), rs182263790 (near RPL19P11), rs530684220 (near LINC01419). PMID:39024449.
The 5 positions lie in or near 5 genes: TRERNA1, PAM16, TBX19, RPL19P11, LINC01419. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Verma A et al. 2024 reported the smallest P value on this page — P = 10-12 — at rs529554850 near TRERNA1.
Association records say which positions differ, on average, between people with Duodenitis and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Nothing on this page diagnoses Duodenitis. The 5 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Duodenitis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Duodenitis. MyGeneLog™. https://www.mygenelog.com/conditions/duodenitis
In the GWAS Catalog, Duodenitis is filed as "Duodenitis (PheCode 535.6)". Rather than define it, this page lists the genome-wide findings: 5 positions from 1 study, each with its study's sample and citation.
Genes play a part: 5 positions have been linked to it, the largest study recording 2,938 cases and 619,683 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The catalogue maps the positions to 5 genes: TRERNA1, PAM16, TBX19, RPL19P11, LINC01419. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Duodenitis from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.