Corneal Ulcer, as genome-wide studies have reported it: 6 positions from 1 study, the largest recording 2,091 cases and 629,795 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
This is the record of what genome-wide association studies have found for Corneal Ulcer (the GWAS Catalog's "Corneal ulcer (PheCode 370.1)"): 6 positions reported by 1 study. The page is put together by code from the catalogue's records and the studies' own listings, and it is rebuilt whenever the records change, so it always reflects them as they stand.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 2,091 cases and 629,795 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). It contributes 6 positions: rs754763810 (near PRR11P1), rs549104783 (near UBE2V2), rs77821854 (SLC9A9), rs544491865 (CCBE1), rs556569191 (ALPK1), rs183215388 (NTF4). PMID:39024449.
The 6 positions sit in or beside 6 genes: PRR11P1, UBE2V2, SLC9A9, CCBE1, ALPK1, NTF4. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Verma A et al. 2024 reported the smallest P value on this page — P = 10-13 — at rs754763810 near PRR11P1.
Read this page as a list of findings about Corneal Ulcer, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Corneal Ulcer is diagnosed by a clinician — not from a genotype. None of the 6 variants on this page is used by any guideline to predict, screen for or diagnose it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Corneal Ulcer comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Corneal Ulcer. MyGeneLog™. https://www.mygenelog.com/conditions/corneal-ulcer
Corneal Ulcer is the condition the GWAS Catalog files under "Corneal ulcer (PheCode 370.1)". This page does not define it in its own words; it lists what genome-wide studies have reported: 6 positions from 1 study, with each study's sample and citation.
Genome-wide studies have reported 6 associated positions; the largest study behind this page recorded 2,091 cases and 629,795 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 6 genes: PRR11P1, UBE2V2, SLC9A9, CCBE1, ALPK1, NTF4. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Corneal Ulcer from a genotype; a clinician diagnoses it.
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