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Congenital Afibrinogenemia, as genome-wide studies have reported it: 15 positions from 1 study. Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
1 study in the GWAS Catalog report 15 positions for Congenital Afibrinogenemia, which the catalogue files as "Congenital afibrinogenemia". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
A study. From it, 15 positions on this page: rs121909621 (FGB), rs121909622 (FGB), rs121909624 (FGB), rs121909625 (FGB), rs146387238 (FGA), rs1553965519 (FGG), rs1578785111 (FGB), rs1578796476 (FGA), and 7 more.
The 15 positions sit in or beside 3 genes: FGB, FGA, FGG. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Read this page as a list of findings about Congenital Afibrinogenemia, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Nothing on this page diagnoses Congenital Afibrinogenemia. The 15 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
Databases, guidelines and references
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Congenital Afibrinogenemia. MyGeneLog™. https://www.mygenelog.com/conditions/congenital-afibrinogenemia
In the GWAS Catalog, Congenital Afibrinogenemia is filed as "Congenital afibrinogenemia". Rather than define it, this page lists the genome-wide findings: 15 positions from 1 study, each with its study's sample and citation.
Genome-wide studies have reported 15 associated positions. Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 3 genes: FGB, FGA, FGG. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Congenital Afibrinogenemia from a genotype; a clinician diagnoses it.
Free to reuse, non-commercially. This page's text is original writing from freely-available research, licensed CC BY-NC 4.0 — share and adapt it with attribution to MyGeneLog™; commercial use is licensed. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.