Complex Regional/central Pain Syndrome, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 3,122 cases and 625,178 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Complex Regional/central Pain Syndrome — filed in the GWAS Catalog as "Complex regional/central pain syndrome (PheCode 355)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 5 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. The catalogue records its sample as 3,122 cases and 625,178 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). From it, 5 positions on this page: rs116935049 (near KIF2B), rs142714744 (near AEN), rs575463074 (near XXYLT1), rs186711928 (near TUBBP9), rs535285063 (near RN7SL679P). PMID:39024449.
The catalogue maps the 5 positions to 5 genes: KIF2B, AEN, XXYLT1, TUBBP9, RN7SL679P. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Verma A et al. 2024 reported the smallest P value on this page — P = 4 × 10-13 — at rs116935049 near KIF2B.
It is a record of what genome-wide studies have reported about Complex Regional/central Pain Syndrome, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Complex Regional/central Pain Syndrome is diagnosed by a clinician — not from a genotype. None of the 5 variants on this page is used by any guideline to predict, screen for or diagnose it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Complex Regional/central Pain Syndrome comes down to these specific, well-studied positions — not a diagnosis.
near KIF2B · rs116935049
See detailed info →near AEN · rs142714744
See detailed info →near XXYLT1 · rs575463074
See detailed info →near TUBBP9 · rs186711928
See detailed info →near RN7SL679P · rs535285063
See detailed info →Databases, guidelines and references
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Complex Regional/central Pain Syndrome. MyGeneLog™. https://www.mygenelog.com/conditions/complex-regional-central-pain-syndrome
In the GWAS Catalog, Complex Regional/central Pain Syndrome is filed as "Complex regional/central pain syndrome (PheCode 355)". Rather than define it, this page lists the genome-wide findings: 5 positions from 1 study, each with its study's sample and citation.
Genome-wide studies have reported 5 associated positions; the largest study behind this page recorded 3,122 cases and 625,178 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 5 genes: KIF2B, AEN, XXYLT1, TUBBP9, RN7SL679P. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Complex Regional/central Pain Syndrome from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.