Cardiomyopathy, as genome-wide studies have reported it: 2 positions from 1 study, the largest recording 7,053 cases and 111,507 controls (African American or Afro-Caribbean ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Genome-wide studies have so far placed 2 positions on Cardiomyopathy, from 1 study; the GWAS Catalog files the condition as "Cardiomyopathy (PheCode 425)". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. The catalogue records its sample as 7,053 cases and 111,507 controls (African American or Afro-Caribbean ancestry). It contributes 2 positions: rs73467637 (DDB2), rs3211916 (CD36). PMID:39024449.
The 2 positions lie in or near 2 genes: DDB2, CD36. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Of all these, rs73467637 in DDB2 carries the strongest signal: P = 4 × 10-16, in Verma A et al. 2024.
It is a record of what genome-wide studies have reported about Cardiomyopathy, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Nothing on this page diagnoses Cardiomyopathy. The 2 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Cardiomyopathy comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Cardiomyopathy. MyGeneLog™. https://www.mygenelog.com/conditions/cardiomyopathy
Cardiomyopathy is the condition the GWAS Catalog files under "Cardiomyopathy (PheCode 425)". This page does not define it in its own words; it lists what genome-wide studies have reported: 2 positions from 1 study, with each study's sample and citation.
Genes play a part: 2 positions have been linked to it, the largest study recording 7,053 cases and 111,507 controls (African American or Afro-Caribbean ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 2 genes: DDB2, CD36. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Cardiomyopathy from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.