Ankylosis of Joint, as genome-wide studies have reported it: 8 positions from 1 study, the largest recording 829 cases and 570,923 controls (African American or Afro-Caribbean ancestry, European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Ankylosis of Joint — filed in the GWAS Catalog as "Ankylosis of joint (PheCode 741.1)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 8 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 829 cases and 570,923 controls (African American or Afro-Caribbean ancestry, European ancestry). The 8 positions on this page from it: rs558111321 (NCOA2), rs370475313 (near DNAJB6P1), rs539337875 (LINC00824), rs149951403 (MIR3681HG), rs549508457 (near ANKRD62), rs185562207 (near LINC01941), rs368409746 (MAFTRR), rs895250373 (SLC1A1). PMID:39024449.
The 8 positions lie in or near 8 genes: NCOA2, DNAJB6P1, LINC00824, MIR3681HG, ANKRD62, LINC01941, MAFTRR, SLC1A1. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Verma A et al. 2024 reported the smallest P value on this page — P = 10-13 — at rs558111321 in NCOA2.
Association records say which positions differ, on average, between people with Ankylosis of Joint and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
A genotype does not diagnose Ankylosis of Joint; a clinician does. No guideline uses the 8 variants on this page to predict it, screen for it or confirm it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Ankylosis of Joint comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Ankylosis of Joint. MyGeneLog™. https://www.mygenelog.com/conditions/ankylosis-of-joint
Ankylosis of Joint is the condition the GWAS Catalog files under "Ankylosis of joint (PheCode 741.1)". This page does not define it in its own words; it lists what genome-wide studies have reported: 8 positions from 1 study, with each study's sample and citation.
Genome-wide studies have reported 8 associated positions; the largest study behind this page recorded 829 cases and 570,923 controls (African American or Afro-Caribbean ancestry, European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 8 genes: NCOA2, DNAJB6P1, LINC00824, MIR3681HG, ANKRD62, LINC01941, MAFTRR, SLC1A1. These are where the positions sit, not proof of how they act.
No. They are population-level findings of small effect. Ankylosis of Joint is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.