Anal and Rectal Polyp, as genome-wide studies have reported it: 6 positions from 1 study, the largest recording 4,766 cases and 607,628 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
Anal and Rectal Polyp — filed in the GWAS Catalog as "Anal and rectal polyp (PheCode 565.1)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 6 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 4,766 cases and 607,628 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). It contributes 6 positions: rs192216216 (near RPA2P2), rs544784219 (CASC15), rs564574705 (near HSPE1P24), rs150501838 (near GPR139), rs571485135 (near UBE2V1P4), rs531841657 (near RNU6-546P). PMID:39024449.
The 6 positions sit in or beside 6 genes: RPA2P2, CASC15, HSPE1P24, GPR139, UBE2V1P4, RNU6-546P. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Verma A et al. 2024 reported the smallest P value on this page — P = 2 × 10-29 — at rs192216216 near RPA2P2.
Read this page as a list of findings about Anal and Rectal Polyp, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Nothing on this page diagnoses Anal and Rectal Polyp. The 6 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Anal and Rectal Polyp comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Anal and Rectal Polyp. MyGeneLog™. https://www.mygenelog.com/conditions/anal-and-rectal-polyp
Anal and Rectal Polyp is the condition the GWAS Catalog files under "Anal and rectal polyp (PheCode 565.1)". This page does not define it in its own words; it lists what genome-wide studies have reported: 6 positions from 1 study, with each study's sample and citation.
Genome-wide studies have reported 6 associated positions; the largest study behind this page recorded 4,766 cases and 607,628 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 6 genes: RPA2P2, CASC15, HSPE1P24, GPR139, UBE2V1P4, RNU6-546P. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Anal and Rectal Polyp from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.