Acute Tonsillitis, as genome-wide studies have reported it: 8 positions from 1 study, the largest recording 1,539 cases and 626,131 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
1 study in the GWAS Catalog report 8 positions for Acute Tonsillitis, which the catalogue files as "Acute tonsillitis (PheCode 474.1)". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 1,539 cases and 626,131 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). It contributes 8 positions: rs538837352 (EGFEM1P), rs143736485 (RAPGEF5), rs142735475 (near LINC01036), rs187654860 (near ADCY8), rs149932975 (near RN7SKP289), rs552949394 (near GTF3AP6), rs151159185 (BRD2), rs537579281 (LINC02755). PMID:39024449.
The catalogue maps the 8 positions to 8 genes: EGFEM1P, RAPGEF5, LINC01036, ADCY8, RN7SKP289, GTF3AP6, BRD2, LINC02755. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Of all these, rs538837352 in EGFEM1P carries the strongest signal: P = 5 × 10-15, in Verma A et al. 2024.
It is a record of what genome-wide studies have reported about Acute Tonsillitis, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
A genotype does not diagnose Acute Tonsillitis; a clinician does. No guideline uses the 8 variants on this page to predict it, screen for it or confirm it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Acute Tonsillitis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Acute Tonsillitis. MyGeneLog™. https://www.mygenelog.com/conditions/acute-tonsillitis
Acute Tonsillitis is the condition the GWAS Catalog files under "Acute tonsillitis (PheCode 474.1)". This page does not define it in its own words; it lists what genome-wide studies have reported: 8 positions from 1 study, with each study's sample and citation.
Genes play a part: 8 positions have been linked to it, the largest study recording 1,539 cases and 626,131 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 8 genes: EGFEM1P, RAPGEF5, LINC01036, ADCY8, RN7SKP289, GTF3AP6, BRD2, LINC02755. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Acute Tonsillitis is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.